Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats
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منابع مشابه
Interactive Effects of Acute and Chronic Lithium with Dopamine Receptor Antagonists on Naloxone-Induced Jumping in Morphine-Dependent Mice
In the present study, interactive effects of D1 and D2 dopamine receptors antagonists and different periods of lithium pretreatment on morphine dependence in mice have been investigated. This study was designed to investigate whether the hypothesis that lithium and dopaminergic mechanisms via their effects on phosphoinositide pathways and calcium flux could influence morphine withdrawal respons...
متن کاملInteractive Effects of Acute and Chronic Lithium with Dopamine Receptor Antagonists on Naloxone-Induced Jumping in Morphine-Dependent Mice
In the present study, interactive effects of D1 and D2 dopamine receptors antagonists and different periods of lithium pretreatment on morphine dependence in mice have been investigated. This study was designed to investigate whether the hypothesis that lithium and dopaminergic mechanisms via their effects on phosphoinositide pathways and calcium flux could influence morphine withdrawal respons...
متن کاملPhasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal.
Nicotine, the main psychoactive ingredient of tobacco smoke, induces negative motivational symptoms during withdrawal that contribute to relapse in dependent individuals. The neurobiological mechanisms underlying how the brain signals nicotine withdrawal remain poorly understood. Using electrophysiological, genetic, pharmacological, and behavioral methods, we demonstrate that tonic but not phas...
متن کاملD1 Receptors in Maoi and Nicotine Self-administration
Tobacco smoking is the leading cause of preventable death in the United States, taking the lives of about 440,000 people (Centers for Disease Control, 2004). It is commonly believed that nicotine is the key agent in the addictive properties of tobacco smoking. Nicotine is a direct agonist of nicotinic acetylcholine receptors, which are largely expressed through the brain. At the present time, n...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2019
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2019.172766